American Airlines flight AA 4221: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 07:00 Chicago O'Hare (ORD) 3 09:10 Indianapolis (IND)
AA 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:10 Effective 2025-10-06 through 2025-11-01
Daily 08:00 Chicago O'Hare (ORD) 3 10:09 Indianapolis (IND)
AA 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:09 Effective 2025-11-02 through 2025-12-02
Daily 08:00 Chicago O'Hare (ORD) 3 10:13 Indianapolis (IND)
AA 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:13 Effective 2025-12-03 through 2025-12-17
Daily 08:00 Chicago O'Hare (ORD) 3 10:15 Indianapolis (IND)
AA 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:15 Effective 2025-12-18 through 2026-01-05
Daily 08:00 Chicago O'Hare (ORD) 3 10:11 Indianapolis (IND)
AA 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:11 Effective 2026-01-06 through 2026-02-11
Daily 10:20 Phoenix Sky Harbor (PHX) 4 12:12 San Luis Obispo (SBP)
AA 4221 Non-stop Embraer EMB 175 (E75) 1:52 Valid until 2025-05-04
Daily 12:51 San Luis Obispo (SBP) 14:34 Phoenix Sky Harbor (PHX) 4
AA 4221 Non-stop Embraer EMB 175 (E75) 1:43 Valid until 2025-05-04
Daily 16:46 Chicago O'Hare (ORD) 3 18:50 Indianapolis (IND)
AA 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:04 Effective 2025-05-05 through 2025-05-22
Mon,Fri,Sun 16:46 Chicago O'Hare (ORD) 3 18:50 Indianapolis (IND)
AA 4221 Non-stop Embraer EMB 175 (E75) 1:04 Effective 2025-05-23 through 2025-05-26
Daily 16:46 Chicago O'Hare (ORD) 3 18:50 Indianapolis (IND)
AA 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:04 Effective 2025-05-27 through 2025-06-04
Daily 21:47 Miami (MIA) 22:56 Tampa (TPA)
AA 4221 Non-stop Embraer EMB 175 (E75) 1:09 Effective 2025-07-05 through 2025-08-05
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4221: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4221
07:00
Chicago O'Hare (ORD) 3

09:10
Indianapolis (IND)
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:10, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4221
08:00
Chicago O'Hare (ORD) 3

10:09
Indianapolis (IND)
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:09, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4221
08:00
Chicago O'Hare (ORD) 3

10:13
Indianapolis (IND)
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:13, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4221
08:00
Chicago O'Hare (ORD) 3

10:15
Indianapolis (IND)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:15, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4221
08:00
Chicago O'Hare (ORD) 3

10:11
Indianapolis (IND)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:11, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4221
10:20
Phoenix Sky Harbor (PHX) 4

12:12
San Luis Obispo (SBP)
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:52, non-stop
Embraer EMB 175 (E75)
American Airlines AA4221
12:51
San Luis Obispo (SBP)

14:34
Phoenix Sky Harbor (PHX) 4
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:43, non-stop
Embraer EMB 175 (E75)
American Airlines AA4221
16:46
Chicago O'Hare (ORD) 3

18:50
Indianapolis (IND)
Effective 2025-05-05 through 2025-05-22
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:04, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4221
16:46
Chicago O'Hare (ORD) 3

18:50
Indianapolis (IND)
Effective 2025-05-23 through 2025-05-26
Mon
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
Duration: 1:04, non-stop
Embraer EMB 175 (E75)
American Airlines AA4221
16:46
Chicago O'Hare (ORD) 3

18:50
Indianapolis (IND)
Effective 2025-05-27 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:04, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4221
21:47
Miami (MIA)

22:56
Tampa (TPA)
Effective 2025-07-05 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:09, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Chicago O'Hare (ORD) - Indianapolis (IND)
  • Miami (MIA) - Tampa (TPA)
  • Phoenix Sky Harbor (PHX) - San Luis Obispo (SBP)
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